GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs302668 | 1 | rs302668 | chr11:87876911 | RAB38 | chr11:87846431-87908599:- | 0.25 | 4.19 | 3.54E-5 | Frontotemporal dementia |
| BLCA | cis | rs30187 | 1 | rs30378 | chr5:96121994 | ERAP1 | chr5:96096515-96149837:- | -0.51 | -10.95 | 1.77E-24 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs30378 | chr5:96121994 | ERAP2 | chr5:96211644-96255398:+ | 0.33 | 5.45 | 9.1E-8 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs30379 | chr5:96122260 | ERAP1 | chr5:96096515-96149837:- | -0.51 | -10.95 | 1.77E-24 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs30379 | chr5:96122260 | ERAP2 | chr5:96211644-96255398:+ | 0.33 | 5.45 | 9.1E-8 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs30380 | chr5:96122281 | ERAP1 | chr5:96096515-96149837:- | -0.51 | -10.95 | 1.77E-24 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs30380 | chr5:96122281 | ERAP2 | chr5:96211644-96255398:+ | 0.33 | 5.45 | 9.1E-8 | Ankylosing spondylitis |
| BLCA | cis | rs3091242 | 1 | rs3091242 | chr1:25674785 | RHD | chr1:25598981-25656935:+ | -0.54 | -9.36 | 7.09E-19 | Erythrocyte sedimentation rate |
| BLCA | cis | rs10461617 | 1 | rs3099459 | chr5:56137170 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 11.44 | 2.94E-26 | Type 2 diabetes |
| BLCA | cis | rs798766 | 1 | rs3099555 | chr4:1725651 | FAM53A | chr4:1641609-1685854:- | -0.34 | -4.98 | 9.81E-7 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs7655841 | 1 | rs3099899 | chr4:129917368 | C4orf33 | chr4:130014829-130033842:+ | -0.32 | -5.31 | 1.83E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs2251844 | 1 | rs3101443 | chr15:43912372 | ADAL | chr15:43622872-43646094:+ | -0.39 | -4.34 | 1.83E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs3101443 | chr15:43912372 | CATSPER2 | chr15:43922774-43959900:- | -0.35 | -5.1 | 5.28E-7 | Tumor biomarkers |
| BLCA | cis | rs7655841 | 1 | rs3105369 | chr4:130022448 | C4orf33 | chr4:130014829-130033842:+ | -0.33 | -5.42 | 1.04E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs3105593 | 1 | rs3105593 | chr15:50845018 | SPPL2A | chr15:50999739-51057910:- | 0.23 | 4.29 | 2.28E-5 | QT interval |